Yes, we plan to improve this in the future when we support moving Spine views into separate windows, so Spine can better span multiple monitors.
For now you can start Spine with a shortcut to set the scale, for example for 200 interface scale:
Windows: Spine --ui-scale 200
Mac: /Applications/Spine.app/Contents/MacOS/Spine --ui-scale 200
Linux: ./Spine.sh --ui-scale 200