I was watching a lynda/ linkedin video: "Start Your Own Game Company with John Romero" in the section "Hiring Game Development Contractors" at 4:25:
"You might decide that you're going to use, say, spline, or Spine, which is a really great tool to take 2D animations and it goes kind of beyond Flash, the way that Flash animates.
But you might need them to know Spine, and how to hook up a Spine skeleton, and how to animate the 2D stuff."
Pretty awesome! I grew up playing Doom/ Wolfenstein/ Quake/Commander Keen.
Interesting that he knows of, and uses Spine!