Hello! I ran into a problem today.
I think I pressed the expand all the windows button in the latest update and it just completely broke. Don't even know ho to fix it now. The mouse detection is offset too, and the buttons do not appear to reset. 
Problem wih ui?
I can't seem to be able to reproduce the problem unfortunately.
In the meantime, you could try to delete the prefs.json file, then start Spine, and see if this fixes the issue:
Windows: <user home folder>\Spine\prefs.json
Mac: <user home folder>/Library/Application Support/Spine/prefs.json
Linux: <user home folder>/.spine/prefs.json
Deleting the prefs.jsn didn't seem to help, but I downloaded the latest 4.3 version, opened a file and it fixed it. After coming back to 4.2 it was still fixed so it works now. But what a bizzare issue
dshanaur Based on the screenshot you provided, it appears that the interface scale was set to 110% when this issue occurred, which may have caused the layout to become distorted. The UI scale has been significantly improved in 4.3-beta, so this issue should not occur in 4.3.
We are working to release 4.3 as a stable version as soon as possible, so we would appreciate it if you could upgrade to 4.3 when it is released.
Thank you for such quick responses btw!
Unfortunately, I need to export Binaries as .skel.bytes and it doesnt have a version export like a .json does and many of our projects are on older versions. Or does it?
In any case at least switching back and forward between versions helps somehow rn.
But it did happen again when I tried to open a minimized window of preview during Setup in Spine 4.2.43
dshanaur Sorry for the confusion. What I recommended was upgrading both your Spine Editor and Spine Runtime at the same time when version 4.3 is released. It is not advisable to export only the skeleton data in the 4.2 format while using the 4.3 editor.
In any case at least switching back and forward between versions helps somehow rn.
We do not guarantee forward compatibility. Doing so would require a significant amount of effort and ultimately make it difficult to add new improvements. Instead, we minimize runtime changes, provide scripts that make it easy to upgrade large amounts of skeleton data, and offer immediate support to users who encounter problems during the upgrade process to make the upgrade easier.
Are you perhaps enabling color management? If so, you may want to set the interface scale back to 100%. In versions prior to 4.3, using an incomplete scale, such as 110%, with color management may cause layout issues.
Color management won't cause layout problems at odd UI scales. Such scales cause minor scaling issues: blurriness or off-by-1-pixel issues, with or without color management. That is much improved in 4.3, where text is always crisp.
Color management could have a bug that causes the weird layout scrambling, so it's worth trying with it off. Strange it seemed to resolve somehow.
Not sure what exactly fixed it, but it is fixed. I put my interface scale to 100 and turned off color management. By the way when the bug happened initially my UI was at 150 percent or 125. On screenshots it was accident as the mouse was offset and I tried to resolve it.