@ninhhongquan You first have to create a bone in the Spine Editor which you bind your path constraint point to. You can test in the Spine Editor if your path constraint point is moving along with the bone when moving the bone around in Animate mode.

Then on the runtime side, you can change the bone location via code as usual. This can be done e.g. via a SkeletonUtilityBone hierarchy where the desired bone is set to Mode Override, or directly via code (using bone.SetLocalPosition()) as in Spine Examples/Getting Started/4 Object Oriented Sample on the VIEW Spineboy GameObject in the SpineboyTargetController script.

@ninhhongquan Glad to hear, thanks for getting back to us!