Welcome to Spine! :nerd:

There are some forum threads related to 8 or 4 direction movement:
Best way to do character with 4 movement directions
Switch skeletons quickly
Basically it boils down to having a parent GameObject with each one of the direction-Skeletons as a child. Then your movement logic script needs to disable all direction-Skeletons except for the active direction (and flip it horizontally if direction is e.g. left instead of right), and play the respective animations there. Note that some animations might need to be synchronized between your Skeletons.

Please note that you could also use a single Spine skeleton for all directions, as shown in this tip:
Spine Tips: 10.8 directions